5-HT1A RECEPTOR FUNCTION IN DEPRESSION - EFFECT OF CHRONIC AMITRIPTYLINE TREATMENT

被引：62

作者：

LESCH, KP

DISSELKAMPTIETZE, J

SCHMIDTKE, A

机构：

[1] Department of Psychiatry, University of Würzburg, Würzburg

来源：

JOURNAL OF NEURAL TRANSMISSION-GENERAL SECTION | 1990年 / 80卷 / 02期

关键词：

5-HT[!sub]1A[!/sub] receptor; amitriptyline; hypothermia; ipsapirone;

D O I：

10.1007/BF01257081

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Hypothermic responses to 5-HT1A receptor activation by the selective ligand ipsapirone (IPS) were attenuated in depressed patients as compared to controls. Chronic treatment with amitriptyline (AMI) further impaired 5-HT1Amediated hypothermia. The results indicate a subsensitive (presynaptic) 5-HT1A receptor and/or a defective post-receptor signalling pathway in depression and are consistent with the hypothesis that 5-HT1A receptors are down-regulted during AMI treatment. © 1990 Springer-Verlag.

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页码：157 / 161

页数：5

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