INFLUENCE OF NON-REM SLEEP ON INSPIRATORY MUSCLE-ACTIVITY AND LUNG-VOLUME IN ASTHMATIC-PATIENTS

To determine the effect of non-REM (NREM) sleep on inspiratory muscle electromyographic (EMG) activity in asthmatic patients and the subsequent effect of such changes on FRC, 12 asthmatic patients with nocturnal worsening were monitored overnight in a horizontal volume-displacement body plethysmograph. During studies FRC was monitored using the single inspiratory occlusion technique, whereas EMG activities of the diaphragm (DI), intercostal (IC), and sternocleidomastoid (SCM) muscles were monitored using surface electrodes. FRC decreased progressively, from 3.63 +/- 0.27 L while awake prior to ''lights out'' to 3.15 +/- 0.27 L after 60 min of NREM sleep (p < 0.005). With awakening at the end of the study FRC increased to 4.69 +/- 0.48 L (p < 0.01). Onset of NREM sleep was also associated with significant (p < 0.05) reductions in EMG tonic activities of all three inspiratory muscles. These levels of tonic activity returned and were further augmented (p < 0.001) with awakening at the conclusion of the study. Linear relationships were demonstrated between sleep-state dependent changes in FRC and EMG tonic activity for each of the three inspiratory muscles (r = 0.98, 0.93, and 0.97 for DI, IC, and SCM, respectively, p < 0.01). NREM sleep did not significantly alter mean inspiratory phasic activities of these muscles, although there was considerable heterogeneity between individual subjects in the effects of NREM sleep. We conclude that in asthmatic patients with nocturnal worsening: (1) NREM sleep is associated with a decrement in inspiratory muscle tonic activity; (2) alterations in inspiratory muscle tonic activity occurring before, during, and after a period of sleep are linearly related to concurrent changes in FRC; (3) sleep-associated decrements in muscle activity may therefore contribute to sleep-associated reductions in FRC.