ADIPOSE-TISSUE METABOLISM IN HUMANS DETERMINED BY VEIN CATHETERIZATION AND MICRODIALYSIS TECHNIQUES

被引:85
作者
SIMONSEN, L
BULOW, J
MADSEN, J
机构
[1] BISPEBJERG HOSP,DEPT NUCL MED,DK-2400 COPENHAGEN,DENMARK
[2] HVIDOVRE UNIV HOSP,DEPT CLIN PHYSIOL,DK-2400 COPENHAGEN,DENMARK
[3] HVIDOVRE UNIV HOSP,DEPT NUCL MED,DK-2400 COPENHAGEN,DENMARK
[4] UNIV COPENHAGEN,PANUM INST,INST MED PHYSIOL C,DK-2200 COPENHAGEN N,DENMARK
来源
AMERICAN JOURNAL OF PHYSIOLOGY | 1994年 / 266卷 / 03期
关键词
BLOOD FLOW; FICKS PRINCIPLE; GAS TENSION; GLUCOSE LOAD; THERMOGENESIS;
D O I
10.1152/ajpendo.1994.266.3.E357
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
A technique for catheterization of a vein draining abdominal subcutaneous tissue and a microdialysis technique that allows measurements of intercellular water concentrations in adipose tissue in humans have recently been described. In the present study, we compare the two techniques during an oral glucose load. In addition a technique using microdialysis for measurement of tissue oxygen and carbon dioxide tensions is described. Microdialysis and vein catheterization were performed in the same region on the abdomen, and the subcutaneous adipose tissue blood flow was measured by the local Xe-133 washout method. The results show that subcutaneous adipose tissue gas tensions are on level with gas tensions measured in abdominal venous blood. Comparison of metabolite concentrations measured in the venous blood and venous blood concentrations calculated from microdialysis data shows that there is good agreement between the concentrations obtained by the two techniques with respect to glucose and glycerol, whereas lactate concentrations are very different. With regard to substrate fluxes calculated by Fick's principle, the catheterization technique is probably the most reliable, considering the numerous assumptions on which calculations of venous concentrations from microdialysis data are based. Advantages and disadvantages of the two techniques are discussed.
引用
收藏
页码:E357 / E365
页数:9
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