ANTIBODY-ANTIGEN INTERACTIONS

被引：254

作者：

WILSON, IA ^{[1
]}

STANFIELD, RL ^{[1
]}

机构：

[1] UNIV CALIF SAN DIEGO, SCRIPPS INST OCEANOG, RES INST, LA JOLLA, CA 92093 USA

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1993年 / 3卷 / 01期

关键词：

D O I：

10.1016/0959-440X(93)90210-C

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Different antibodies adopt substantially different shapes in order to recognize their respective antigens. Local and more global structural rearrangements, in addition to sequence and size diversity of complementarity determining loops, result in antigen-binding sites that can vary considerably in size, shape and charge distribution, even though the antibody framework structure remains invariant. The structures of several free and bound Fabs show that induced-fit mechanisms best describe the antibody-antigen recognition process. This affects the prediction, engineering and design of antibody combining sites.

引用

页码：113 / 118

页数：6

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