INFLUENCE OF SIALOADENECTOMY ON CAPSAICIN-SENSITIVE GASTRIC DEFENSE-MECHANISM IN RATS

被引：4

作者：

EVANGELISTA, S ^{[1
]}

MAGGI, CA ^{[1
]}

机构：

[1] MENARINI PHARMACEUT,DEPT PHARMACOL,I-50131 FLORENCE,ITALY

来源：

JAPANESE JOURNAL OF PHARMACOLOGY | 1991年 / 56卷 / 03期

关键词：

D O I：

10.1254/jjp.56.377

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

Chemical ablation of sensory afferents produced by the treatment with the neurotoxin capsaicin worsened gastric ulcers induced by 50% ethanol in sham-and sialoadenectomized (SALX)-operated rats. Conversely, capsaicin worsened water immersion stress (WIS)-ulcers in SALX, but not those in sham-operated animals. The concomitant removal of two potent antisecretory factors, such as salivary gland containing epidermal growth factor and neuropeptides contained in the sensory afferents, is probably responsible for the enhanced vulnerability of the mucosa in WIS-ulcers.

引用

页码：377 / 380

页数：4

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