C9-IMINO AND C10-AMINO DERIVATIVES OF ASCOMYCIN (21-ETHYL-FK 506)

被引:11
作者
NUSSBAUMER, P
GRASSBERGER, M
SCHULZ, G
机构
[1] SANDOZ Forschungsinstitut Wien, A-1235 Wien
关键词
D O I
10.1016/S0040-4039(00)74800-3
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Treatment of Ascomycin (21-ethyl-FK 506) with ammonia in alcoholic solution yields C9-imine 5 and C10-amine 6, whereas methylamine gives only C9-methylimine 10.
引用
收藏
页码:3845 / 3846
页数:2
相关论文
共 6 条
[1]  
ARAI T, 1962, J ANTIBIOT, V15, P231
[2]   C10 N-ACYL MODIFIED FK-506 - A POSSIBLE HYBRID ANALOG OF THE TRANSITION-STATE OF PEPTIDYL-PROLYL CIS-TRANS ISOMERIZATION [J].
DONALD, DK ;
COOPER, ME ;
FURBER, M ;
WELLS, E ;
HUTCHINSON, R ;
BLACK, FM .
TETRAHEDRON LETTERS, 1991, 32 (10) :1375-1378
[3]  
INAMINE ES, 1990, Patent No. 349061
[4]   CONFORMATIONAL-ANALYSIS OF THE CIS-ISOMERS AND TRANSISOMERS OF FK506 BY NMR AND MOLECULAR-DYNAMICS [J].
MIERKE, DF ;
SCHMIEDER, P ;
KARUSO, P ;
KESSLER, H .
HELVETICA CHIMICA ACTA, 1991, 74 (05) :1027-1047
[5]   STRUCTURE OF FK506 - A NOVEL IMMUNOSUPPRESSANT ISOLATED FROM STREPTOMYCES [J].
TANAKA, H ;
KURODA, A ;
MARUSAWA, H ;
HATANAKA, H ;
KINO, T ;
GOTO, T ;
HASHIMOTO, M ;
TAGA, T .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1987, 109 (16) :5031-5033
[6]   RAPAMYCIN (AY-22,989), A NEW ANTIFUNGAL ANTIBIOTIC .1. TAXONOMY OF PRODUCING STREPTOMYCETE AND ISOLATION OF ACTIVE PRINCIPLE [J].
VEZINA, C ;
KUDELSKI, A ;
SEHGAL, SN .
JOURNAL OF ANTIBIOTICS, 1975, 28 (10) :721-726