TRANSCRIPTIONAL ORGANIZATION OF A 450-KB REGION OF THE HUMAN X-CHROMOSOME IN XQ28

被引：71

作者：

BIONE, S ^{[1
]}

TAMANINI, F ^{[1
]}

MAESTRINI, E ^{[1
]}

TRIBIOLI, C ^{[1
]}

POUSTKA, A ^{[1
]}

TORRI, G ^{[1
]}

RIVELLA, S ^{[1
]}

TONIOLO, D ^{[1
]}

机构：

[1] GERMAN CANC RES CTR,W-6900 HEIDELBERG,GERMANY

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1993年 / 90卷 / 23期

关键词：

CPG ISLANDS; CDNA; HUMAN GENOME; HUMAN GENES;

D O I：

10.1073/pnas.90.23.10977

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In this paper, we report the transcriptional organization of a 450-kb gene cluster in Xq28, flanked hy the glucose-6-phosphate dehydrogenase and the color vision genes. CpG islands previously identified and mapped to distal Xq28 have helped in construction of a continuous contig of cosmids and in identification of cDNAs corresponding to eight transcripts. Thirteen to 16 small genes with CpG islands are clustered in a region of 250-300 kb. Many are highly expressed in muscle or brain and may be the genes responsible for muscle or neurological disorders mapped to distal Xq28. Our analysis indicates that, in this region of the genome, genes not related in sequence are organized in transcriptional domains of 100 kb and that this organization may be important for establishing and regulating gene expression in relation to tissue distribution and X chromosome inactivation.

引用

页码：10977 / 10981

页数：5

共 24 条

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