LIGANDS FOR THE STUDY OF SWEET TASTE RECEPTORS - SYNTHESIS OF FLUORESCENT N,N'-DISUBSTITUTED GUANIDINEACETIC ACIDS

被引：7

作者：

SULIKOWSKI, MM

KIM, K

SULIKOWSKI, GA

NAGARAJAN, S

LINTHICUM, DS

机构：

[1] TEXAS A&M UNIV, DEPT CHEM, COLLEGE STN, TX 77843 USA

[2] TEXAS A&M UNIV, DEPT BIOCHEM & BIOPHYS, COLLEGE STN, TX 77843 USA

[3] TEXAS A&M UNIV, DEPT VET PATHOBIOL, COLLEGE STN, TX 77843 USA

[4] MONSANTO CO, ST LOUIS, MO 63198 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 23期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0960-894X(95)00501-J

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of three different fluorescent N,N'-disubstituted guanidino acetic acids with intense sweet taste properties is reported. The preparation of disubstituted guanidino acetic acids containing an alpha-naphthylamine, beta-naphthylamine or methylcoumarin substitution produced compounds with fluorescent properties which will make them useful for spectroscopic studies of sweetener-receptor binding site interactions.

引用

页码：2875 / 2878

页数：4

共 13 条

[1] COMPUTER-AIDED MOLECULAR MODELING OF THE BINDING-SITE ARCHITECTURE FOR 8 MONOCLONAL-ANTIBODIES THAT BIND A HIGH POTENCY GUANIDINIUM SWEETENER [J].