PROTEIN OXIDATIVE DAMAGE IS ASSOCIATED WITH LIFE EXPECTANCY OF HOUSEFLIES

被引：295

作者：

SOHAL, RS

AGARWAL, S

DUBEY, A

ORR, WC

机构：

[1] Department of Biological Sciences, Southern Methodist University, Dallas

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1993年 / 90卷 / 15期

关键词：

AGING; OXYGEN FREE RADICALS; PROTEIN OXIDATION; OXIDATIVE STRESS;

D O I：

10.1073/pnas.90.15.7255

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The objective of this study was to test some of the predictions of the oxidative-stress hypothesis of aging, which postulates that aging is causally associated with the molecular damage inflicted by reactive oxygen species. Protein carbonyl content was used as an index of molecular oxidative modifications. The carbonyl content was found to be associated with the physiological age or life expectancy of flies rather than with their chronological age. Exposure of flies to sublethal hyperoxia (100% oxygen) irreversibly enhanced the carbonyl content of the flies and decreased their rate of oxygen consumption. Results of this study indicate that protein carbonyl content may be a biomarker of aging and support the general concept that oxidative stress may be a causal factor in the aging process.

引用

页码：7255 / 7259

页数：5

共 34 条

[21] HYDROGEN-PEROXIDE RELEASE BY MITOCHONDRIA INCREASES DURING AGING [J].