THE CYTOCHROMES P450 AND MECHANISMS OF CHEMICAL CARCINOGENESIS

被引：65

作者：

PARKE, DV

机构：

来源：

ENVIRONMENTAL HEALTH PERSPECTIVES | 1994年 / 102卷 / 10期

关键词：

CHEMICAL CARCINOGENESIS; CYTOCHROME P450; PROTEIN KINASE C; REACTIVE OXYGEN SPECIES;

D O I：

10.2307/3432116

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

This article reviews mechanisms of chemical carcinogenesis, from metabolic activation and generation of reactive oxygen species by cytochromes P4511 and P4502E to DNA damage, activation of protein kinase C and ocogenes, hyperplasia, and proteoglycan changes in the cell glycocalyx and lysosomal enzymes which mediate invasion and metastasis.

引用

页码：852 / 853

页数：2

共 34 条

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