POTENTIATION OF PHENCYCLIDINE-INDUCED DOPAMINE RELEASE IN THE RAT STRIATUM BY THE BLOCKADE OF DOPAMINE D-2 RECEPTOR

被引：5

作者：

YONEZAWA, Y ^{[1
]}

KUROKI, T ^{[1
]}

TASHIRO, N ^{[1
]}

HONDO, H ^{[1
]}

UCHIMURA, H ^{[1
]}

机构：

[1] HIZEN NATL MENTAL HOSP,CTR EMOT & BEHAV DISORDERS,NEUROCHEM LAB,KANZAKI,SAGA 84201,JAPAN

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1995年 / 285卷 / 03期

关键词：

PHENCYCLIDINE; DOPAMINE D-1 RECEPTOR ANTAGONIST; DOPAMINE D-2 RECEPTOR ANTAGONIST; STRIATUM; RAT; MICRODIALYSIS;

D O I：

10.1016/0014-2999(95)00527-R

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Local perfusion with phencyclidine (PCP) increased extracellular dopamine levels in the rat striatum in a dose-dependent manner, as measured by in vivo microdialysis. While pretreatment with SCH 23390, a selective dopamine D-1 receptor antagonist, had no significant effect on PCP-induced increases in extracellular dopamine levels, pretreatment with YM-09151-2 (cis-N-(1-benzyl-2-methylpyrrolidin-3-yl)-5-chloro-2-methoxy-4-methylaminobenzamide), a selective dopamine D-2 receptor antagonist, markedly potentiated the effect of PCP. These results suggest that the blockade of dopamine D-2 presynaptic autoreceptors strongly potentiates the PCP-induced dopamine release in the striatum.

引用

页码：305 / 308

页数：4

共 15 条

[1] DIRECT IN-VIVO EVIDENCE THAT D2 DOPAMINE-RECEPTORS CAN MODULATE DOPAMINE UPTAKE [J].

CASS, WA ;

GERHARDT, GA .

NEUROSCIENCE LETTERS, 1994, 176 (02) :259-263

[2]

DOHERTY JD, 1980, EUR J PHARMACOL, V65, P139, DOI 10.1016/0014-2999(80)90386-6

[3]

GIROS B, 1992, MOL PHARMACOL, V42, P383

[4] EFFECT OF PHENCYCLIDINE ON DOPAMINE RELEASE IN THE RAT PREFRONTAL CORTEX - AN IN-VIVO MICRODIALYSIS STUDY [J].

HONDO, H ;

YONEZAWA, Y ;

NAKAHARA, T ;

NAKAMURA, K ;

HIRANO, M ;

UCHIMURA, H ;

TASHIRO, N .

BRAIN RESEARCH, 1994, 633 (1-2) :337-342

[5] CA-2+ DEPENDENCE OF THE AMPHETAMINE, NOMIFENSINE, AND LU-19-005 EFFECT ON INVIVO DOPAMINE TRANSMISSION [J].

HURD, YL ;

UNGERSTEDT, U .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1989, 166 (02) :261-269

[6]

JAVITT DC, 1991, AM J PSYCHIAT, V148, P1301

[7] SCH-23390 EQUIVALENTLY, BUT YM-09151-2 DIFFERENTIALLY REDUCES THE STIMULANT EFFECTS OF METHAMPHETAMINE, MK-801 AND KETAMINE - ASSESSMENT BY DISCRETE SHUTTLE AVOIDANCE IN MICE [J].

KURIBARA, H ;

UCHIHASHI, Y .

JAPANESE JOURNAL OF PHARMACOLOGY, 1993, 62 (01) :111-114

[8]

MURRAY TF, 1978, LIFE SCI, V24, P2217

[9] FLUNARIZINE POTENTIATES COCAINE-INDUCED DOPAMINE RELEASE AND MOTOR STIMULATION IN RATS [J].

PANI, L ;

KUZMIN, A ;

STEFANINI, E ;

GESSA, GL ;

ROSSETTI, ZL .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1990, 190 (1-2) :223-227

[10] CALCIUM RECEPTOR ANTAGONISTS MODIFY COCAINE EFFECTS IN THE CENTRAL-NERVOUS-SYSTEM DIFFERENTLY [J].

PANI, L ;

KUZMIN, A ;

DIANA, M ;

DEMONTIS, G ;

GESSA, GL ;

ROSSETTI, ZL .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1990, 190 (1-2) :217-221

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