AGE-RELATED ALTERATION IN EXCITATORY AMINO-ACID NEUROTRANSMISSION IN RAT-BRAIN

被引：41

作者：

NAJLERAHIM, A ^{[1
]}

FRANCIS, PT ^{[1
]}

BOWEN, DM ^{[1
]}

机构：

[1] INST NEUROL,MIRIAM MARKS DEPT NEUROCHEM,1 WAKEFIELD ST,LONDON WC1N 1PJ,ENGLAND

来源：

NEUROBIOLOGY OF AGING | 1990年 / 11卷 / 02期

关键词：

Excitatory amino acids; Nucleus basalis of Meynert;

D O I：

10.1016/0197-4580(90)90049-6

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The excitatory amino acids as neurotransmitters in the neocortex, hippocampus, striatum, thalamus, amygdala, nucleus basalis of Meynert and cerebellum from rats aged 4 months, 12 months and 24 months have been examined by measuring sodium-dependent high affinity uptake of D-[3H]-aspartate into preparations containing synaptosomes. Calcium-dependent K+-stimulated release of endogenous glutamate from the nucleus basalis was also measured. The hippocampus and cerebellum failed to show significant age-related changes in uptake of D-[3H]-aspartate. D-[3H]-aspartate uptake decreased significantly in the neocortex (29%), striatum (29%), nucleus basalis (26%), amygdala (19%) and thalamus (16%) in the middle-aged rats as compared to the young rats, but the changes were not progressive with age. The release of glutamate from the nucleus basalis was unaltered during the aging process. © 1990.

引用

页码：155 / 158

页数：4

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