AGE-RELATED ALTERATION IN EXCITATORY AMINO-ACID NEUROTRANSMISSION IN RAT-BRAIN

被引：41

作者：

NAJLERAHIM, A ^{[1
]}

FRANCIS, PT ^{[1
]}

BOWEN, DM ^{[1
]}

机构：

[1] INST NEUROL,MIRIAM MARKS DEPT NEUROCHEM,1 WAKEFIELD ST,LONDON WC1N 1PJ,ENGLAND

来源：

NEUROBIOLOGY OF AGING | 1990年 / 11卷 / 02期

关键词：

Excitatory amino acids; Nucleus basalis of Meynert;

D O I：

10.1016/0197-4580(90)90049-6

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The excitatory amino acids as neurotransmitters in the neocortex, hippocampus, striatum, thalamus, amygdala, nucleus basalis of Meynert and cerebellum from rats aged 4 months, 12 months and 24 months have been examined by measuring sodium-dependent high affinity uptake of D-[3H]-aspartate into preparations containing synaptosomes. Calcium-dependent K+-stimulated release of endogenous glutamate from the nucleus basalis was also measured. The hippocampus and cerebellum failed to show significant age-related changes in uptake of D-[3H]-aspartate. D-[3H]-aspartate uptake decreased significantly in the neocortex (29%), striatum (29%), nucleus basalis (26%), amygdala (19%) and thalamus (16%) in the middle-aged rats as compared to the young rats, but the changes were not progressive with age. The release of glutamate from the nucleus basalis was unaltered during the aging process. © 1990.

引用

页码：155 / 158

页数：4

共 27 条

[11] FORMATION AND TURNOVER OF NEURONS IN YOUNG AND SENESCENT ANIMALS - AN ELECTRON-MICROSCOPIC AND MORPHOMETRIC ANALYSIS [J].

KAPLAN, MS .

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1985, 457 :173-192

[12] GAMMA-AMINOBUTYRIC ACID CONCENTRATION IN BRAIN-TISSUE AT 2 STAGES OF ALZHEIMERS-DISEASE [J].

LOWE, SL ;

FRANCIS, PT ;

PROCTER, AW ;

PALMER, AM ;

DAVISON, AN ;

BOWEN, DM .

BRAIN, 1988, 111 :785-799

[13]

NAJLERAHIM A, 1988, BIOCHEM J, V251, P205

[14]

PEARSON RCA, IN PRESS REV NEUROSC

[15] THE CHOLINERGIC HYPOTHESIS - 10 YEARS ON [J].

PERRY, EK .

BRITISH MEDICAL BULLETIN, 1986, 42 (01) :63-69

[16] AGE-RELATED-CHANGES IN GLUTAMATE CONCENTRATION AND SYNAPTOSOMAL GLUTAMATE UPTAKE IN ADULT-RAT STRIATUM [J].

PRICE, MT ;

OLNEY, JW ;

HAFT, R .

LIFE SCIENCES, 1981, 28 (12) :1365-1370

[17] EVIDENCE OF GLUTAMATERGIC DENERVATION AND POSSIBLE ABNORMAL-METABOLISM IN ALZHEIMERS-DISEASE [J].

PROCTER, AW ;

PALMER, AM ;

FRANCIS, PT ;

LOWE, SL ;

NEARY, D ;

MURPHY, E ;

DOSHI, R ;

BOWEN, DM .

JOURNAL OF NEUROCHEMISTRY, 1988, 50 (03) :790-802

[18]

PROCTER AW, 1988, BANBURY REPORT, V27, P3

[19]

RAPOPORT SI, 1983, AGING, V22, P111

[20] REDUCTION OF CORTICAL DOPAMINE, NORADRENALINE, SEROTONIN AND THEIR METABOLITES IN PARKINSONS-DISEASE [J].

SCATTON, B ;

JAVOYAGID, F ;

ROUQUIER, L ;

DUBOIS, B ;

AGID, Y .

BRAIN RESEARCH, 1983, 275 (02) :321-328

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