ONLINE ISOTACHOPHORETIC ANALYTE FOCUSING FOR IMPROVEMENT OF DETECTION LIMITS IN CAPILLARY ELECTROPHORESIS ELECTROSPRAY MASS-SPECTROMETRY

被引：41

作者：

TINKE, AP ^{[1
]}

REINHOUD, NJ ^{[1
]}

NIESSEN, WMA ^{[1
]}

TJADEN, UR ^{[1
]}

VANDERGREEF, J ^{[1
]}

机构：

[1] LEIDEN UNIV,CTR BIOPHARMACEUT SCI,DIV ANALYT CHEM,POB 9502,2300 RA LEIDEN,NETHERLANDS

来源：

RAPID COMMUNICATIONS IN MASS SPECTROMETRY | 1992年 / 6卷 / 09期

关键词：

D O I：

10.1002/rcm.1290060905

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Detectability enhancement in capillary electrophoresis/mass spectrometry (CE/MS) has been realized using on-line isotachophoretic (ITP) analyte focusing. This is demonstrated for the analysis of a mixture of anthracyclines, showing an at least 200-fold improvement in minimum detectable concentration for ITP/CE/MS compared to CE/MS using an electrospray (ESP) interface.

引用

页码：560 / 563

页数：4