INHIBITORY EFFECT OF THE IMMUNOSUPPRESSANT FK506 ON APOPTOTIC CELL-DEATH INDUCED BY HIV-1 GP120

被引：29

作者：

SEKIGAWA, I

KOSHINO, K

HISHIKAWA, T

KANEKO, H

TAKASAKI, Y

HASHIMOTO, H

HIROSE, S

INAGAKI, Y

YAMAMOTO, N

机构：

[1] JUNTENDO UNIV, IZU NAGAOKA HOSP, SCH MED, DEPT MED, SHIZUOKA 41022, JAPAN

[2] TOKYO MED & DENT UNIV, SCH MED, DEPT MICROBIOL, BUNKYO KU, TOKYO 113, JAPAN

来源：

JOURNAL OF CLINICAL IMMUNOLOGY | 1995年 / 15卷 / 06期

关键词：

HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 (HIV-1); GP120; APOPTOSIS; TUMOR NECROSIS FACTOR-ALPHA; FK506;

D O I：

10.1007/BF01541321

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Human immunodeficiency virus type 1 (HTV-1) envelope glycoprotein gp120 may play a central role in inducing immunoregulatory disorders after HIV infection. The apoptotic death of normal human peripheral blood mononuclear cells was induced by priming with gp120 followed by stimulation with an anti-T cell receptor (TCR) antibody. Tumor necrosis factor-alpha produced by gp120-binding macrophages may be important to induce this cell death. Treatment of gp120-primed cells with an immunosuppressant (FK506) before TCR signaling inhibited apoptotic cell death, and this blocking effect of FK506 was concentration dependent. FK506 did not have any influence on cell growth and viability over the range of concentrations tested. These findings suggest that FK506 is a potentially useful drug in delaying the onset of AIDS after HIV infection.

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收藏

页码：312 / 317

页数：6

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