ION-SELECTIVE ELECTRODE FOR PROCAINAMIDE DETERMINATION IN BLOOD-SERUM

被引：22

作者：

KATSU, T ^{[1
]}

FURUNO, K ^{[1
]}

YAMASHITA, S ^{[1
]}

GOMITA, Y ^{[1
]}

机构：

[1] OKAYAMA UNIV,SCH MED,DEPT HOSP PHARM,OKAYAMA 700,JAPAN

来源：

ANALYTICA CHIMICA ACTA | 1995年 / 312卷 / 01期

关键词：

ION SELECTIVE ELECTRODES; PROCAINAMIDE; BLOOD ANALYSIS; SERUM; DRUG MONITORING;

D O I：

10.1016/0003-2670(95)00196-7

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A procainamide-selective electrode was constructed and applied for the determination of procainamide concentration in blood serum. The detection limit was 1.5 mu g ml(-1), but determination down to 0.5 mu g ml(-1) was possible with an appropriate calibration. The results correlated well with those obtained by a fluorescence polarization immunoassay which is widely used for the determination of serum procainamide concentration. The present method is simple, rapid, economical and is unaffected by common cations present in blood and only slightly by N-acetylprocainamide, a metabolite of the drug. It is therefore useful for therapeutic drug monitoring in a clinical setting.

引用

页码：35 / 38

页数：4

共 11 条

[1]

BERTHOLF RL, 1988, CLIN CHEM, V34, P1500

[2]

HAYASHI M, 1985, SAISHIN KENSA, V3, P11

[3]

IGA T, 1993, TDM NO JISSAI

[4] ION-SELECTIVE ELECTRODE FOR SERUM BROMIDE ASSAY IN PATIENTS WITH EPILEPSY [J].