THE EFFECT OF ALLOPURINOL ON NA+K+ATPASE RELATED LIPID-PEROXIDATION IN ISCHEMIC AND REPERFUSED RABBIT KIDNEY

被引：21

作者：

ARICIOGLU, A ^{[1
]}

AYDIN, S ^{[1
]}

TURKOZKAN, N ^{[1
]}

DURMUS, O ^{[1
]}

机构：

[1] GAZI UNIV, FAC MED, DEPT GEN SURG, ANKARA, TURKEY

来源：

GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM | 1994年 / 25卷 / 02期

关键词：

NA+K+ATPASE; LIPID PEROXIDATION; ALLOPURINOL; KIDNEY;

D O I：

10.1016/0306-3623(94)90064-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. Na+K+ATPase is a membrane bound enzyme whose activity is essential for maintenance of cell viability. Lipid peroxidation changes membrane fluidity and enzyme activity. 2. The purpose of this study was to investigate the effect of allopurinol (free radical scavenger) on Na+K+ATPase activity in rabbit kidney cortex membrane. In this in vivo study we created ischemia and reperfusion in rabbit kidneys. 3. Enzyme activity were low in ischemic and reperfused kidneys, compared to the controls. In allopurinol treated ischemic and reperfused groups, the levels of Na+K+ATPase activity were high compared to the untreated group. 4. It has been concluded that allopurinol may protect this enzyme activity.

引用

页码：341 / 344

页数：4

共 28 条

[21] STEWART JR, 1985, J THORAC CARDIOV SUR, V90, P68
[22] BINDING OF UNSATURATED FATTY-ACIDS TO NA+,K+-ATPASE LEADING TO INHIBITION AND INACTIVATION
SWARTS, HGP
STEKHOVEN, FMAHS
DEPONT, JJHHM
[J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1990, 1024 (01) : 32 - 40
[23] RADICAL-INDUCED INACTIVATION OF KIDNEY NA+,K+-ATPASE - SENSITIVITY TO MEMBRANE LIPID-PEROXIDATION AND THE PROTECTIVE EFFECT OF VITAMIN-E
THOMAS, CE
REED, DJ
[J]. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1990, 281 (01) : 96 - 105
[24] CHARACTERIZATION OF GLUTATHIONE-DEPENDENT INHIBITION OF LIPID-PEROXIDATION OF ISOLATED RAT-LIVER NUCLEI
TIRMENSTEIN, MA
REED, DJ
[J]. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1988, 261 (01) : 1 - 11
[25] DETERMINATION OF MALONALDEHYDE PRECURSOR IN TISSUES BY THIOBARBITURIC ACID TEST
UCHIYAMA, M
MIHARA, M
[J]. ANALYTICAL BIOCHEMISTRY, 1978, 86 (01) : 271 - 278
[26] WEISS SJ, 1986, ACTA PHYSIOL SCAND, V126, P9
[27] STUDIES ON THE SPECIFICITY OF THE EFFECTS OF OXYGEN METABOLITES ON CARDIAC SODIUM-PUMP
XIE, ZJ
WANG, YH
ASKARI, A
HUANG, WH
KLAUNIG, JE
ASKARI, A
[J]. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 1990, 22 (08) : 911 - 920
[28] POSTISCHEMIC CEREBRAL LIPID-PEROXIDATION INVITRO - MODIFICATION BY DIETARY VITAMIN-E
YOSHIDA, S
BUSTO, R
WATSON, BD
SANTISO, M
GINSBERG, MD
[J]. JOURNAL OF NEUROCHEMISTRY, 1985, 44 (05) : 1593 - 1601

← 1 2 3 →