NITRIC-OXIDE AS A SECRETORY PRODUCT OF MAMMALIAN-CELLS

被引:4171
作者
NATHAN, C
机构
[1] Division of Hematology-Oncology, Department of Medicine, Cornell University Medical College, New York
关键词
NO BIOSYNTHESIS; CEREBELLAR NITRIC OXIDE SYNTHASE; L-ARGININE;
D O I
10.1096/fasebj.6.12.1381691
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Evolution has resorted to nitric oxide (NO), a tiny, reactive radical gas, to mediate both servoregulatory and cytotoxic functions. This article reviews how different forms of nitric oxide synthase help confer specificity and diversity on the effects of this remarkable signaling molecule.
引用
收藏
页码:3051 / 3064
页数:14
相关论文
共 163 条
[1]   REDOX REGULATION OF FOS AND JUN DNA-BINDING ACTIVITY INVITRO [J].
ABATE, C ;
PATEL, L ;
RAUSCHER, FJ ;
CURRAN, T .
SCIENCE, 1990, 249 (4973) :1157-1161
[2]   NG-METHYLARGININE, AN INHIBITOR OF ENDOTHELIUM-DERIVED NITRIC-OXIDE SYNTHESIS, IS A POTENT PRESSOR AGENT IN THE GUINEA-PIG - DOES NITRIC-OXIDE REGULATE BLOOD-PRESSURE INVIVO [J].
AISAKA, K ;
GROSS, SS ;
GRIFFITH, OW ;
LEVI, R .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 160 (02) :881-886
[3]  
ALBINA JE, 1991, J IMMUNOL, V147, P144
[4]   THE L-ARGININE DEPENDENT EFFECTOR MECHANISM IS INDUCED IN MURINE ADENOCARCINOMA CELLS BY CULTURE SUPERNATANT FROM CYTO-TOXIC ACTIVATED MACROPHAGES [J].
AMBER, IJ ;
HIBBS, JB ;
TAINTOR, RR ;
VAVRIN, Z .
JOURNAL OF LEUKOCYTE BIOLOGY, 1988, 43 (02) :187-192
[5]   BENEFICIAL-EFFECTS OF 2 FORMS OF NO ADMINISTRATION IN FELINE SPLANCHNIC ARTERY-OCCLUSION SHOCK [J].
AOKI, N ;
JOHNSON, G ;
LEFER, AM .
AMERICAN JOURNAL OF PHYSIOLOGY, 1990, 258 (02) :G275-G281
[6]   NITRIC-OXIDE ACTIVATES GUANYLATE CYCLASE AND INCREASES GUANOSINE 3'-5'-CYCLIC MONOPHOSPHATE LEVELS IN VARIOUS TISSUE PREPARATIONS [J].
ARNOLD, WP ;
MITTAL, CK ;
KATSUKI, S ;
MURAD, F .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (08) :3203-3207
[7]   REDOX REGULATION OF A PROTEIN TYROSINE KINASE IN THE ENDOPLASMIC-RETICULUM [J].
BAUSKIN, AR ;
ALKALAY, I ;
BEN-NERIAH, Y .
CELL, 1991, 66 (04) :685-696
[8]   APPARENT HYDROXYL RADICAL PRODUCTION BY PEROXYNITRITE - IMPLICATIONS FOR ENDOTHELIAL INJURY FROM NITRIC-OXIDE AND SUPEROXIDE [J].
BECKMAN, JS ;
BECKMAN, TW ;
CHEN, J ;
MARSHALL, PA ;
FREEMAN, BA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (04) :1620-1624
[9]   CACHECTIN AND TUMOR-NECROSIS-FACTOR AS 2 SIDES OF THE SAME BIOLOGICAL COIN [J].
BEUTLER, B ;
CERAMI, A .
NATURE, 1986, 320 (6063) :584-588
[10]   MODULATION OF NITROGEN-OXIDE SYNTHESIS INVIVO - NG-MONOMETHYL-L-ARGININE INHIBITS ENDOTOXIN-INDUCED NITRITE NITRATE BIOSYNTHESIS WHILE PROMOTING HEPATIC DAMAGE [J].
BILLIAR, TR ;
CURRAN, RD ;
HARBRECHT, BG ;
STUEHR, DJ ;
DEMETRIS, AJ ;
SIMMONS, RL .
JOURNAL OF LEUKOCYTE BIOLOGY, 1990, 48 (06) :565-569