NITRIC-OXIDE AS A SECRETORY PRODUCT OF MAMMALIAN-CELLS

被引：4171

作者：

NATHAN, C

机构：

[1] Division of Hematology-Oncology, Department of Medicine, Cornell University Medical College, New York

来源：

FASEB JOURNAL | 1992年 / 6卷 / 12期

关键词：

NO BIOSYNTHESIS; CEREBELLAR NITRIC OXIDE SYNTHASE; L-ARGININE;

D O I：

10.1096/fasebj.6.12.1381691

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Evolution has resorted to nitric oxide (NO), a tiny, reactive radical gas, to mediate both servoregulatory and cytotoxic functions. This article reviews how different forms of nitric oxide synthase help confer specificity and diversity on the effects of this remarkable signaling molecule.

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页码：3051 / 3064

页数：14

相关论文

共 163 条

[31] TUMOR-NECROSIS-FACTOR AND GRANULOCYTE MACROPHAGE-COLONY STIMULATING FACTOR STIMULATE HUMAN MACROPHAGES TO RESTRICT GROWTH OF VIRULENT MYCOBACTERIUM-AVIUM AND TO KILL AVIRULENT MYCOBACTERIUM-AVIUM - KILLING EFFECTOR MECHANISM DEPENDS ON THE GENERATION OF REACTIVE NITROGEN INTERMEDIATES [J].

DENIS, M .

JOURNAL OF LEUKOCYTE BIOLOGY, 1991, 49 (04) :380-387

[32]

DING A, 1990, J IMMUNOL, V145, P940

[33]

DING AH, 1988, J IMMUNOL, V141, P2407

[34] IMPAIRMENT OF ENDOTHELIUM-DEPENDENT PULMONARY-ARTERY RELAXATION IN CHRONIC OBSTRUCTIVE LUNG-DISEASE [J].

DINHXUAN, AT ;

HIGENBOTTAM, TW ;

CLELLAND, CA ;

PEPKEZABA, J ;

CREMONA, G ;

BUTT, AY ;

LARGE, SR ;

WELLS, FC ;

WALLWORK, J .

NEW ENGLAND JOURNAL OF MEDICINE, 1991, 324 (22) :1539-1547

[35] GLUCOCORTICOIDS INHIBIT THE INDUCTION OF NITRIC-OXIDE SYNTHASE IN MACROPHAGES [J].

DIROSA, M ;

RADOMSKI, M ;

CARNUCCIO, R ;

MONCADA, S .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1990, 172 (03) :1246-1252

[36]

DRAPIER JC, 1991, J BIOL CHEM, V266, P10162

[37] INTERFERON-GAMMA AND TUMOR NECROSIS FACTOR INDUCE THE L-ARGININE-DEPENDENT CYTO-TOXIC EFFECTOR MECHANISM IN MURINE MACROPHAGES [J].

DRAPIER, JC ;

WIETZERBIN, J ;

HIBBS, JB .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1988, 18 (10) :1587-1592

[38] CORRECTION OF ENDOTHELIAL DYSFUNCTION IN CORONARY MICROCIRCULATION OF HYPERCHOLESTEROLEMIC PATIENTS BY L-ARGININE [J].

DREXLER, H ;

ZEIHER, AM ;

MEINZER, K ;

JUST, H .

LANCET, 1991, 338 (8782-3) :1546-1550

[39]

DUPUY PM, 1992, IN PRESS J CLIN INVE

[40] THE OBLIGATORY ROLE OF ENDOTHELIAL-CELLS IN THE RELAXATION OF ARTERIAL SMOOTH-MUSCLE BY ACETYLCHOLINE [J].

FURCHGOTT, RF ;

ZAWADZKI, JV .

NATURE, 1980, 288 (5789) :373-376

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