BEHAVIORAL TOXICITY OF ANTICHOLINESTERASES IN PRIMATES - CHRONIC PYRIDOSTIGMINE AND SOMAN INTERACTIONS

被引：27

作者：

BLICK, DW ^{[1
]}

KERENYI, SZ ^{[1
]}

MILLER, S ^{[1
]}

MURPHY, MR ^{[1
]}

BROWN, GC ^{[1
]}

HARTGRAVES, SL ^{[1
]}

机构：

[1] USAF,SCH AEROSP MED,DIV RADIAT SCI,BROOKS AFB,TX 78235

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1991年 / 38卷 / 03期

关键词：

BEHAVIORAL TOXICOLOGY; BEHAVIORAL PHARMACOLOGY; ORGANOPHOSPHATE; CARBAMATE; CHOLINERGIC SYSTEMS; RHESUS MONKEYS; COMPENSATORY TRACKING;

D O I：

10.1016/0091-3057(91)90008-P

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Dose rates for continuous infusion of pyridostigmine bromide require to inhibit 30% and 60% of normal serum cholinesterase activity in rhesus monkeys were determined. The effects of continuous pyridostigmine infusion at these dose-rates on the behavioral toxicity of 5 daily repeated low-dose exposures to a toxic organophosphate (soman) were determined no to be deleterious; in fact, they were slightly (and variably) protective. Relative to controls (5-day soman ED50 = 0.89-mu-g/kg/day), pyridostigmine infusions producing 30% and 60% inhibition produced 5-day ED50s of 1.25 and 1.11-mu-g/kg/day), respectively. Variability in response to the pyridostigmine-soman combinations appeared to be greater than in response to daily soman exposure without pyridostigmine infusion.

引用

页码：527 / 532

页数：6

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