EXCITATORY ACTION OF SOME ASPARTATE-CONTAINING AND GLUTAMATE-CONTAINING DIPEPTIDES AFTER INTRACEREBROVENTRICULAR INJECTION IN MICE

被引：8

作者：

GARYAEV, AP ^{[1
]}

DUMPIS, MA ^{[1
]}

POZNJAKOVA, LN ^{[1
]}

ZAITZEV, YV ^{[1
]}

PIOTROVSKY, LB ^{[1
]}

机构：

[1] ACAD MED SCI USSR, INST EXPTL MED, DEPT PHARMACOL, ACAD PAVLOV ST 12, LENINGRAD 197022, USSR

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1991年 / 197卷 / 2-3期

关键词：

ALPHA-NAAG (N-ACETYL-ALPHA-L-ASPARTYL-L-GLUTAMATE); PEPTIDES; SEIZURES; (MOUSE);

D O I：

10.1016/0014-2999(91)90515-R

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effects of some dipeptides, analogues of N-acetyl-alpha-L-aspartyl-L-glutamate, were studied after i.c.v. administration into mice in acute experiments. N-Acetyl-alpha-L-aspartyl-L-glutamate itself did not induce seizures in animals, but prevented glutamate-induced convulsions. All other dipeptides possessed excitatory glutamate-like actions. Some structural requirements for the excitatory effects of the dipeptides are discussed.

引用

页码：157 / 160

页数：4

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