MOLECULAR-STRUCTURE OF HUMAN PROTAMINE-P4 (HP4), A MINOR BASIC-PROTEIN OF HUMAN SPERM NUCLEI

被引:33
作者
ARKHIS, A
MARTINAGE, A
SAUTIERE, P
CHEVAILLIER, P
机构
[1] UNIV PARIS 12,BIOL CELLULAIRE LAB,F-94010 CRETEIL,FRANCE
[2] UNIV LILLE 2,INST RECH CANC,CNRS,URA 409,F-59800 LILLE,FRANCE
来源
EUROPEAN JOURNAL OF BIOCHEMISTRY | 1991年 / 200卷 / 02期
关键词
D O I
10.1111/j.1432-1033.1991.tb16196.x
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Protamine HP4 is a minor protein which was purified from human sperm nuclei. It was characterized by its amino acid composition, peptide mapping after digestion with highly specific endoproteinases and finally by its amino acid sequence. Protamine HP4 contains high amounts of arginine, cysteine and histidine. The primary structure of the protein was established by sequence analysis of intact protamine and of its fragments. HP4 is a P2-type protamine of 58 residues (M(r) 7783) structurally related to human protamines HP2 and HP3 from which it only differs by an amino-terminal extension of one and four residues, respectively. These three protamines exhibit a close structural relationship with mouse protamine mP2. The heterogeneity of protamines in human sperm nuclei is discussed.
引用
收藏
页码:387 / 392
页数:6
相关论文
共 17 条
[1]   RAT SPERM PROTAMINE - ISOLATION AND SEQUENCE-ANALYSIS [J].
AMMER, H ;
HENSCHEN, A .
BIOLOGICAL CHEMISTRY HOPPE-SEYLER, 1988, 369 (12) :1301-1306
[2]   ISOLATION AND AMINO-ACID-SEQUENCE ANALYSIS OF HUMAN-SPERM PROTAMINE-P1 AND PROTAMINE-P2 - OCCURRENCE OF 2 FORMS OF PROTAMINE-P2 [J].
AMMER, H ;
HENSCHEN, A ;
LEE, CH .
BIOLOGICAL CHEMISTRY HOPPE-SEYLER, 1986, 367 (06) :515-522
[3]   ABERRANT PROTAMINE-1 PROTAMINE-2 RATIOS IN SPERM OF INFERTILE HUMAN MALES [J].
BALHORN, R ;
REED, S ;
TANPHAICHITR, N .
EXPERIENTIA, 1988, 44 (01) :52-55
[4]   PURIFICATION AND CHARACTERIZATION OF MOUSE PROTAMINE-P1 AND PROSTAMINE-P2 - AMINO-ACID SEQUENCE OF P2 [J].
BELLVE, AR ;
MCKAY, DJ ;
RENAUX, BS ;
DIXON, GH .
BIOCHEMISTRY, 1988, 27 (08) :2890-2897
[5]  
BRETZEL G, 1972, H-S Z PHYSIOL CHEM, V353, P1362
[6]   GENOMIC SEQUENCES OF HUMAN PROTAMINES WHOSE GENES, PRM1 AND PRM2, ARE CLUSTERED [J].
DOMENJOUD, L ;
NUSSBAUM, G ;
ADHAM, IM ;
GREESKE, G ;
ENGEL, W .
GENOMICS, 1990, 8 (01) :127-133
[7]   PURIFICATION AND CHARACTERIZATION OF NUCLEAR BASIC-PROTEINS OF HUMAN-SPERM [J].
GUSSE, M ;
SAUTIERE, P ;
BELAICHE, D ;
MARTINAGE, A ;
ROUX, C ;
DADOUNE, JP ;
CHEVAILLIER, P .
BIOCHIMICA ET BIOPHYSICA ACTA, 1986, 884 (01) :124-134
[8]  
Hecht N.B., 1989, P396
[9]   MOLECULAR CHARACTERIZATION OF NUCLEAR BASIC-PROTEIN HPI1, A PUTATIVE PRECURSOR OF HUMAN SPERM PROTAMINES HP2 AND HP3 [J].
MARTINAGE, A ;
ARKHIS, A ;
ALIMI, E ;
SAUTIERE, P ;
CHEVAILLIER, P .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1990, 191 (02) :449-451
[10]   HUMAN-SPERM PROTAMINES - AMINO-ACID-SEQUENCES OF 2 FORMS OF PROTAMINE-P2 [J].
MCKAY, DJ ;
RENAUX, BS ;
DIXON, GH .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1986, 156 (01) :5-8