SYNTHESIS AND ANTI-HIV ACTIVITY OF NEW UREA AND NITROSOUREA DERIVATIVES OF DIAMINO ACIDS

被引：9

作者：

DULUDE, H ^{[1
]}

SALVADOR, R ^{[1
]}

GALLANT, G ^{[1
]}

机构：

[1] UNIV MONTREAL, FAC PHARM, MED CHEM LAB, MONTREAL, PQ H3C 3J7, Canada

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 1995年 / 3卷 / 02期

关键词：

D O I：

10.1016/0968-0896(95)00008-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of N'-methyl, N'-allyl, N'-(2-chloroethyl) and N'-propargyl urea and nitrosourea derivatives of diamino acids (L-ornithine and L-lysine) was synthesized and was shown to have weak activity in counteracting the cytopathic effects of the HIV-1 on a T-4 lymphocyte cell line (CEM-IW). However, selected compounds may possess some immunomodulatory activity.

引用

页码：151 / 160

页数：10

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