Cytokines and invertebrate immune responses

被引：69

作者：

Ottaviani, E ^{[1
]}

Franchini, A ^{[1
]}

Cassanelli, S ^{[1
]}

Genedani, S ^{[1
]}

机构：

[1] UNIV MODENA,DEPT BIOMED SCI,PHARMACOL SECT,I-41100 MODENA,ITALY

来源：

BIOLOGY OF THE CELL | 1995年 / 85卷 / 01期

关键词：

cytokines; molluscs; immune responses; nitric oxide synthase; evolution;

D O I：

10.1016/0248-4900(96)89130-1

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A profound interrelationship between cytokines and invertebrate (molluscs) immune responses has been reported. Different cytokines (IL-1 alpha, IL-2 and TNF-alpha significantly stimulate molluscan hemocyte motility, increasing phagocytic activity and provoking the induction of nitric oxide synthase. As far as cell motility is concerned, the response to different cytokines varied between species. These and other recently reported findings (Ottaviani et al (1994) FEES Lett 351, 19-21; Ottaviani et al (1995) Biochem Biophys Res Commun 207, 288-292) suggest that cytokines are important, ancestral, and functionally conserved molecules, which have also maintained their pleiotropicity, redundancy in the mode of action, and high promiscuity of their receptors during evolution.

引用

页码：87 / 91

页数：5

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