Cytokines and invertebrate immune responses

被引：69

作者：

Ottaviani, E ^{[1
]}

Franchini, A ^{[1
]}

Cassanelli, S ^{[1
]}

Genedani, S ^{[1
]}

机构：

[1] UNIV MODENA,DEPT BIOMED SCI,PHARMACOL SECT,I-41100 MODENA,ITALY

来源：

BIOLOGY OF THE CELL | 1995年 / 85卷 / 01期

关键词：

cytokines; molluscs; immune responses; nitric oxide synthase; evolution;

D O I：

10.1016/0248-4900(96)89130-1

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A profound interrelationship between cytokines and invertebrate (molluscs) immune responses has been reported. Different cytokines (IL-1 alpha, IL-2 and TNF-alpha significantly stimulate molluscan hemocyte motility, increasing phagocytic activity and provoking the induction of nitric oxide synthase. As far as cell motility is concerned, the response to different cytokines varied between species. These and other recently reported findings (Ottaviani et al (1994) FEES Lett 351, 19-21; Ottaviani et al (1995) Biochem Biophys Res Commun 207, 288-292) suggest that cytokines are important, ancestral, and functionally conserved molecules, which have also maintained their pleiotropicity, redundancy in the mode of action, and high promiscuity of their receptors during evolution.

引用

页码：87 / 91

页数：5

共 39 条

[11] INVERTEBRATE IMMUNOCYTES - RELATIONSHIP BETWEEN PHAGOCYTOSIS AND NITRIC-OXIDE PRODUCTION [J].

FRANCHINI, A ;

FONTANILI, P ;

OTTAVIANI, E .

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY, 1995, 110 (02) :403-407

[12] MOLECULAR-CLONING AND EXPRESSION OF INDUCIBLE NITRIC-OXIDE SYNTHASE FROM HUMAN HEPATOCYTES [J].

GELLER, DA ;

LOWENSTEIN, CJ ;

SHAPIRO, RA ;

NUSSLER, AK ;

DISILVIO, M ;

WANG, SC ;

NAKAYAMA, DK ;

SIMMONS, RL ;

SNYDER, SH ;

BILLIAR, TR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (08) :3491-3495

[13] INTERLEUKIN-1 ACTIVITY IN HEMOLYMPH FROM STRAINS OF THE SNAIL BIOMPHALARIA-GLABRATA VARYING IN SUSCEPTIBILITY TO THE HUMAN BLOOD FLUKE, SCHISTOSOMA-MANSONI - PRESENCE, DIFFERENTIAL EXPRESSION, AND BIOLOGICAL FUNCTION [J].

GRANATH, WO ;

CONNORS, VA ;

TARLETON, RL .

CYTOKINE, 1994, 6 (01) :21-27

[14] USE OF AVIDIN-BIOTIN-PEROXIDASE COMPLEX (ABC) IN IMMUNOPEROXIDASE TECHNIQUES - A COMPARISON BETWEEN ABC AND UNLABELED ANTIBODY (PAP) PROCEDURES [J].

HSU, SM ;

RAINE, L ;

FANGER, H .

JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 1981, 29 (04) :577-580

[15]

HUGHES TK, 1992, ACTA BIOL HUNG, V43, P269

[16] INTERACTION OF IMMUNOACTIVE MONOKINES (INTERLEUKIN-1 AND TUMOR-NECROSIS-FACTOR) IN THE BIVALVE MOLLUSK MYTILUS-EDULIS [J].

HUGHES, TK ;

SMITH, EM ;

CHIN, R ;

CADET, P ;

SINISTERRA, J ;

LEUNG, MK ;

SHIPP, MA ;

SCHARRER, B ;

STEFANO, GB .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (12) :4426-4429

[17]

HUGHES TK, 1991, PROG NEUROENDOCRINIM, V4, P234

[18] CYTOKINES AND ENDOCRINE FUNCTION - AN INTERACTION BETWEEN THE IMMUNE AND NEUROENDOCRINE SYSTEMS [J].

IMURA, H ;

FUKATA, J ;

MORI, T .

CLINICAL ENDOCRINOLOGY, 1991, 35 (02) :107-115

[19] SHARING OF THE INTERLEUKIN-2 (IL-2) RECEPTOR GAMMA-CHAIN BETWEEN RECEPTORS FOR IL-2 AND IL-4 [J].

KONDO, M ;

TAKESHITA, T ;

ISHII, N ;

NAKAMURA, M ;

WATANABE, S ;

ARAI, K ;

SUGAMURA, K .

SCIENCE, 1993, 262 (5141) :1874-1877

[20] COMMON SUBUNITS OF CYTOKINE RECEPTORS AND THE FUNCTIONAL REDUNDANCY OF CYTOKINES [J].

MIYAJIMA, A ;

HARA, T ;

KITAMURA, T .

TRENDS IN BIOCHEMICAL SCIENCES, 1992, 17 (10) :378-382

← 1 2 3 4 →