2 NEW MACROLIDE SESQUITERPENE PYRIDINE ALKALOIDS FROM MAYTENUS EMARGINATA - EMARGINATINE-G AND THE CYTOTOXIC EMARGINATINE-F

被引：74

作者：

KUO, YH

KING, ML

CHEN, CF

CHEN, HY

CHEN, CH

CHEN, K

LEE, KH

机构：

[1] NATL DEF MED CTR, SCH PHARM, TAIPEI, TAIWAN

[2] NATL INST PREVENT MED, DEPT HLTH, TAIPEI, TAIWAN

[3] UNIV N CAROLINA, SCH PHARM, DIV MED CHEM & NAT PROD, NAT PROD LAB, CHAPEL HILL, NC 27599 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 1994年 / 57卷 / 02期

关键词：

D O I：

10.1021/np50104a011

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new macrolide sesquiterpene pyridine alkaloids, emarginatine F [1] and emarginatine G [2], were isolated from Maytenus emarginata. The structural determinations of 1 and 2 by 2D nmr techniques and spectral comparison with a related compound, emarginatine A [3], are discussed. Biological evaluation showed that emarginatine F [1] demonstrated strong cytotoxicity against human epidermoid carcinoma of the nasopharynx (KB), ileocecal adenocarcinoma (HCT-8), melanoma (RPMI-7951) and medulloblastoma (TE-671) tumor cells, and against murine leukemia (P-388).

引用

页码：263 / 269

页数：7

共 11 条

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