SOLUTION STRUCTURE OF AN UNUSUALLY STABLE RNA TETRAPLEX CONTAINING G-QUARTET AND U-QUARTET STRUCTURES

被引：251

作者：

CHEONG, CJ ^{[1
]}

MOORE, PB ^{[1
]}

机构：

[1] YALE UNIV, DEPT CHEM, 225 PROSPECT ST, NEW HAVEN, CT 06511 USA

来源：

BIOCHEMISTRY | 1992年 / 31卷 / 36期

关键词：

D O I：

10.1021/bi00151a003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A model for the solution structure of an RNA tetraplex, (rUGGGGU)4, has been obtained by two-dimensional NMR spectroscopy and molecular dynamics. The molecule is parallel stranded and Hoogsteen base-paired in 50 mM KCl, and it is so stable that three of its six imino protons have exchange half-lives measured in days at 40-degrees-C. The tetraplex is stabilized by base stacking and by the hydrogen bonds in four G quartets and at least one U quartet. This is the first indication of the existence of U-quartet structures of which we are aware.

引用

页码：8406 / 8414

页数：9

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