EXPERIMENTAL NMR TECHNIQUES FOR STUDIES OF PROTEIN LIGAND INTERACTIONS

被引：61

作者：

OTTING, G

机构：

[1] Karolinska Institutet, Stockholm

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1993年 / 3卷 / 05期

关键词：

D O I：

10.1016/0959-440X(93)90061-O

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

NMR studies of protein-ligand interactions range from using NMR as a tool with which to monitor ligand binding to the determination of the three-dimensional structure of complexes at atomic resolution. In recent years, selective and uniform enrichment with stable isotopes has promoted the investigation of ever larger systems at increasing resolution, and significant advances have been made using NMR techniques that focus specifically on the interaction of proteins and ligands.

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页码：760 / 768

页数：9

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