NEONATAL URINARY URIC-ACID CERATININE RATIO AS AN ADDITIONAL MARKER OF PERINATAL ASPHYXIA

被引：30

作者：

BADER, D ^{[1
]}

GOZAL, D ^{[1
]}

WEINGERABEND, M ^{[1
]}

BERGER, A ^{[1
]}

LANIR, A ^{[1
]}

机构：

[1] TECHNION ISRAEL INST TECHNOL,BNAI ZION MED CTR,DEPT BIOCHEM,IL-31048 HAIFA,ISRAEL

来源：

EUROPEAN JOURNAL OF PEDIATRICS | 1995年 / 154卷 / 09期

关键词：

PERINATAL ASPHYXIA; URIC ACID; CREATININE;

D O I：

10.1007/BF02276720

中图分类号：

R72 [儿科学];

学科分类号：

100202 [儿科学];

摘要：

The diagnosis and evaluation of perinatal asphyxia can be problematic and objective means of assessing its severity are lacking. To study the validity of urinary uric acid as a marker of the degree of perinatal asphyxia, the ratio of urinary uric acid to creatinine (UA/Cr) in urine specimens obtained after birth was measured in two groups of infants. Eighteen term infants with Apgar scores less than or equal to 5 at 5 min and/or an umbilical cord blood pH less than or equal to 7.2, and a base deficit greater than or equal to 12 meq/l were compared to 50 healthy controls. The severity of the perinatal asphyxia was determined by using an ASPHYXIA SCORE. The UA/Cr was higher in the asphyxiated group when compared to controls. (2.06 +/- 1.12, vs. 0.64 +/- 0.48; P < 0.001). Within the perinatal asphyxia group, a significant correlation was found between the UA/Cr ratio and the asphyxia score. (r = 0.86, P < 0.01). Conclusion Infants with perinatal asphyxia have a significantly higher urinary UA/Cr ratio. This may be used as an indicator of the severity of perinatal asphyxia.

引用

页码：747 / 749

页数：3

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