SYNTHETIC INVESTIGATION ON ISOTHIAZOLO-[5,4-B]-PYRIDINES AND ISOTHIAZOLO-[4,5-C]-PYRIDINES

被引：11

作者：

CHIMICHI, S

NESI, R

PONTICELLI, F

TEDESCHI, P

机构：

[1] UNIV FLORENCE,DIPARTIMENTO CHIM ORGAN UGO SCHIFF,CNR,VIA GINO CAPPONI 9,I-50121 FLORENCE,ITALY

[2] UNIV SIENA,IST CHIM ORGAN,I-53100 SIENA,ITALY

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1990年 / 05期

关键词：

D O I：

10.1039/p19900001477

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Different approaches to the title ring systems were examined, based on the cleavage of the N-O bond in the isoxazolopyridine-4-thiols (3) and (4) which afforded the hydroxy derivatives (6) and (7), respectively, in moderate to good yields. 3-Methylisothiazolo-[5,4-b]- and -[4,5-c]-pyridine (11) and (18), as well as several functionalized derivatives, were easily obtained from these key intermediates through the corresponding 4,6-dichloroisothiazolopyridines (10) and (17).

引用

页码：1477 / 1480

页数：4

共 15 条

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MONGE, A ;

MARTINEZMERINO, V ;

FERNANDEZALVAREZ, E .

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[12] METAL-CARBONYL-INDUCED REACTION OF ISOXAZOLES - RING CLEAVAGE AND REDUCTION BY HEXACARBONYLMOLYBDENUM, PENTACARBONYLIRON, OR NONACARBONYLDI-IRON [J].

NITTA, M ;

KOBAYASHI, T .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1985, (07) :1401-1406

[13]

SCHAPER W, 1985, SYNTHESIS-STUTTGART, P861

[14]

SKOTSCH C, 1979, SYNTHESIS-STUTTGART, P370

[15]

ZAWISZA T, 1985, FARMACO-ED SCI, V40, P124

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