SELECTIVE BINDING AND TRANSCYTOSIS OF ULEX-EUROPAEUS-1 LECTIN BY MOUSE PEYERS-PATCH M-CELLS IN-VIVO

被引：71

作者：

CLARK, MA ^{[1
]}

JEPSON, MA ^{[1
]}

SIMMONS, NL ^{[1
]}

HIRST, BH ^{[1
]}

机构：

[1] UNIV NEWCASTLE UPON TYNE,SCH MED,DEPT PHYSIOL SCI,NEWCASTLE TYNE NE2 4HH,TYNE & WEAR,ENGLAND

来源：

CELL AND TISSUE RESEARCH | 1995年 / 282卷 / 03期

基金：

英国惠康基金;

关键词：

LECTIN; ULEX EUROPAEUS 1; PEYERS PATCHES; FOLLICLE ASSOCIATED EPITHELIUM; M-CELLS; TRANSCYTOSIS; IN VIVO; MOUSE (BALB/C);

D O I：

10.1007/BF00318877

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The in vivo interaction of the lectin Ulex europaeus agglutinin 1 with mouse Peyer's patch follicle-associated epithelial cells was studied in the mouse Peyer's patch gut loop model by immunofluorescence and electron microscopy. The lectin targets to mouse Peyer's patch M-cells and is rapidly endocytosed and transcytosed. These processes are accompanied by morphological changes in the M-cell microvilli and by redistribution of polymerised actin. The demonstration of selective binding and uptake of a lectin by intestinal M-cells in vivo suggests that M-cell-specific surface glycoconjugates might act as receptors for the selective adhesion/uptake of microorganisms.

引用

页码：455 / 461

页数：7

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