PHYTIC ACID IN HEALTH AND DISEASE

被引:234
作者
ZHOU, JR [1 ]
ERDMAN, JW [1 ]
机构
[1] UNIV ILLINOIS, DIV NUTR SCI, URBANA, IL 61801 USA
关键词
PHYTIC ACID; ZINC; IRON; CALCIUM; COLON CANCER; RENAL STONE; HEART DISEASE; 2ND-MESSENGER;
D O I
10.1080/10408399509527712
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
Phytic acid (PA), a major phosphorus storage compound of most seeds and cereal grains, contributes about 1 to 7% of their dry weight. It may account for more than 70% of the total kernel phosphorus. PA has the strong ability to chelate multivalent metal ions, especially zinc, calcium, and iron. The binding can result in very insoluble salts that are poorly absorbed from the gastrointestinal tract, which results in poor bioavailability (BV) of minerals. Alternatively, the ability of PA to chelate minerals has been reported to have some protective effects, such as decreasing iron-mediated colon cancer risk and lowering serum cholesterol and triglycerides in experimental animals. Data from human studies are still lacking. PA is also considered to be a natural antioxidant and is suggested to have potential functions of reducing lipid peroxidation and as a preservative in foods. Finally, certain inositol phosphates, which may be derived from PA, have been noted to have a function in second messenger transduction systems. The potential nutritional significance of PA is discussed in this review.
引用
收藏
页码:495 / 508
页数:14
相关论文
共 172 条
[1]   URINARY-EXCRETION OF LIGNANS AND ISOFLAVONOID PHYTOESTROGENS IN JAPANESE MEN AND WOMEN CONSUMING A TRADITIONAL JAPANESE DIET [J].
ADLERCREUTZ, H ;
HONJO, H ;
HIGASHI, A ;
FOTSIS, T ;
HAMALAINEN, E ;
HASEGAWA, T ;
OKADA, H .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 1991, 54 (06) :1093-1100
[2]  
ALI HI, 1991, CEREAL CHEM, V68, P234
[3]  
ANDERSEN DA, 1969, RENAL STONE RES S, P7
[4]   ZINC ANTAGONIZING EFFECTS OF FISH-MEAL, WHEAT BRAN AND A CORN-SOYBEAN MEAL MIXTURE WHEN ADDED TO A PHYTATE-FREE AND FIBER-FREE CASEIN-DEXTROSE DIET [J].
BAKER, DH ;
HALPIN, KM .
NUTRITION RESEARCH, 1988, 8 (02) :213-218
[5]  
BATEN A, 1989, Proceedings of the American Association for Cancer Research Annual Meeting, V30, P182
[6]   INOSITOL-PHOSPHATE-INDUCED ENHANCEMENT OF NATURAL-KILLER CELL-ACTIVITY CORRELATES WITH TUMOR SUPPRESSION [J].
BATEN, A ;
ULLAH, A ;
TOMAZIC, VJ ;
SHAMSUDDIN, AM .
CARCINOGENESIS, 1989, 10 (09) :1595-1598
[7]  
BERDANIER CD, 1992, NUTR TODAY, V27, P22
[8]   INOSITOL TRISPHOSPHATE AND DIACYLGLYCEROL - 2 INTERACTING 2ND MESSENGERS [J].
BERRIDGE, MJ .
ANNUAL REVIEW OF BIOCHEMISTRY, 1987, 56 :159-193
[9]   INOSITOL PHOSPHATES AND CELL SIGNALING [J].
BERRIDGE, MJ ;
IRVINE, RF .
NATURE, 1989, 341 (6239) :197-205
[10]   INOSITOL TRISPHOSPHATE, A NOVEL 2ND MESSENGER IN CELLULAR SIGNAL TRANSDUCTION [J].
BERRIDGE, MJ ;
IRVINE, RF .
NATURE, 1984, 312 (5992) :315-321