TEMPLATE ASSEMBLED SYNTHETIC PROTEINS - CONDENSATION OF A MULTIFUNCTIONAL PEPTIDE TO A TOPOLOGICAL TEMPLATE VIA CHEMOSELECTIVE LIGATION

被引：53

作者：

TUCHSCHERER, G

机构：

[1] Institute of Organic Chemistry, University of Lausanne, CH-1005 Lausanne

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 52期

基金：

瑞士国家科学基金会;

关键词：

TEMPLATE ASSEMBLED SYNTHETIC PROTEINS; CHEMOSELECTIVE LIGATION; MULTIFUNCTIONAL PEPTIDE; TOPOLOGICAL TEMPLATE; OXIME BOND FORMATION;

D O I：

10.1016/S0040-4039(00)61348-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A chemoselective ligation via oxime bond formation is used for the chemical synthesis of template assembled peptides according to the TASP (Template Assembled Synthetic Proteins) approach. Aminooxyacetylation of the multifunctional partial sequence Lys- Arg- Asp- Ser of lactoferrin and subsequent condensation in aqueous solution with a topological template containing four selectively addressable aldehyde functions as attachment sites gives readily access to the TASP molecule.

引用

收藏

页码：8419 / 8422

页数：4

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