SYNTHESIS OF A 4-HELIX BUNDLE-LIKE TEMPLATE-ASSEMBLED SYNTHETIC PROTEIN (TASP) BY CONDENSATION OF A PROTECTED PEPTIDE ON A CONFORMATIONALLY CONSTRAINED CYCLIC CARRIER

被引：32

作者：

ERNEST, I

VUILLEUMIER, S

FRITZ, H

MUTTER, M

机构：

[1] UNIV LAUSANNE, FAC SCI, CHIM SECT, CH-1005 LAUSANNE, SWITZERLAND

[2] UNIV BASEL, INST ORGAN CHEM, CH-4056 BASEL, SWITZERLAND

[3] CIBA GEIGY AG, CH-4002 BASEL, SWITZERLAND

来源：

TETRAHEDRON LETTERS | 1990年 / 31卷 / 28期

关键词：

D O I：

10.1016/S0040-4039(00)94486-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We describe the condensation in solution of a fully protected helix model peptide to a cyclic peptide template including a new turn-inducing mimic to obtain a 4-helix bundle protein-like TASP. This approach allows the total synthesis of chemically and structurally welldefined protein models in the 6-10 kDa range. © 1990.

引用

页码：4015 / 4018

页数：4

共 19 条

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