MICROBIAL HYDROXYLATION OF SCLAREOL

被引：12

作者：

ABRAHAM, WR

机构：

[1] GBF-Gesellschaft für Biotechnologische Forschung mbH, D-38124 Braunschweig

来源：

PHYTOCHEMISTRY | 1994年 / 36卷 / 06期

关键词：

CUNNINGHAMELLA ELEGANS; ZYGOMYCETES; SCLAREOL; DITERPENE; MICROBIAL HYDROXYLATION; PHYLOGENY;

D O I：

10.1016/S0031-9422(00)89734-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Biotransformation of sclareol with different microorganisms led to 2 alpha-, 3 beta- and 18-hydroxy-sclareol. Cunninghamella elegans additionally formed the hitherto unknown 19-hydroxy-sclareol. The phylogenetic position of a strain is mirrored in its ability to form these metabolites. The ability of fungi to convert this substrate is higher than that of the bacteria. Thus 2 alpha-hydroxy-sclareol is only formed by zygomycotina and some deuteromycotina. The most active strains belong to the zygomycotina and basidiomycotina. Within the bacteria, Gram-positive bacteria are more active than Gram-negative ones.

引用

页码：1421 / 1424

页数：4

共 12 条

[1] MICROBIAL FORMATION OF CAPARRAPIDIOL AND DERIVATIVES FROM TRANS-NEROLIDOL [J].