TRANSCELLULAR TRANSACTIVATION BY THE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 TAT PROTEIN

被引:112
作者
HELLAND, DE [1 ]
WELLES, JL [1 ]
CAPUTO, A [1 ]
HASELTINE, WA [1 ]
机构
[1] HARVARD UNIV,SCH MED,DANA FARBER CANC INST,DIV HUMAN RETROVIROL,44 BINNEY ST,BOSTON,MA 02115
关键词
D O I
10.1128/JVI.65.8.4547-4549.1991
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The human immunodeficiency virus type 1 (HIV-1) transactivator (tat) protein produced in one cell activated HIV-1 promoter-directed gene expression in a second cell, provided the cells were in direct contact with one another. This observation suggests that the tat protein produced in HIV-1-infected cells has a physiological effect on neighboring cells.
引用
收藏
页码:4547 / 4549
页数:3
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