COMPARISON OF CARBON-MONOXIDE AND NITROGEN INDUCED EFFECTS ON SYNAPTIC TRANSMISSION IN THE RAT HIPPOCAMPAL SLICE

被引：4

作者：

DOOLETTE, DJ ^{[1
]}

KERR, DIB ^{[1
]}

机构：

[1] UNIV ADELAIDE,DEPT ANEASTHESIA & INTENS CARE,ADELAIDE,SA 5001,AUSTRALIA

来源：

NEUROSCIENCE LETTERS | 1992年 / 138卷 / 01期

关键词：

CARBON MONOXIDE; HYPOXIA; FIELD POTENTIAL; SYNAPTIC TRANSMISSION; HIPPOCAMPUS;

D O I：

10.1016/0304-3940(92)90460-O

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A comparison has been made of the effects of carbon monoxide (CO) or nitrogen (N2) exposure on synaptic transmission in the hippocampal slice. CA1 field potentials, evoked by Schaffer collateral stimulation, were unaffected by superfusion of slices with artificial cerebral spinal fluid (ACSF) equilibrated with either 15% CO or 15% N2 for 120 min. However, superfusion with hypoxic ACSF equilibrated with either 85% CO Or 85% N2 caused a rapid depression of synaptic transmission. Reperfusion with control ACSF following 30 min hypoxia led to recovery of evoked responses and a slight hyperexcitability. In the hippocampal slice. synaptic transmission. as assessed by input/output curves, was not different during or following hypoxia induced by exposure to CO or N2. In the short term, CO is not toxic.

引用

页码：9 / 13

页数：5

共 36 条

[11] GLUTAMATE, NITRIC-OXIDE AND CELL CELL SIGNALING IN THE NERVOUS-SYSTEM [J].

GARTHWAITE, J .

TRENDS IN NEUROSCIENCES, 1991, 14 (02) :60-67

[12] THE ADENOSINE ANTAGONIST 8-CYCLOPENTYLTHEOPHYLLINE REDUCES THE DEPRESSION OF HIPPOCAMPAL NEURONAL RESPONSES DURING HYPOXIA [J].

GRIBKOFF, VK ;

BAUMAN, LA ;

VANDERMAELEN, CP .

BRAIN RESEARCH, 1990, 512 (02) :353-357

[13] THE EFFECT OF CARBON-MONOXIDE ON RESPIRATION [J].

HAAB, P .

EXPERIENTIA, 1990, 46 (11-12) :1202-1206

[14]

HALDANE JBS, 1927, BIOCHEM J, V11, P1068

[15] EXPERIMENTAL CYANIDE ENCEPHALOPATHY - ELECTRON MICROSCOPIC OBSERVATIONS OF EARLY LESIONS IN WHITE MATTER [J].

HIRANO, A ;

LEVINE, S ;

ZIMMERMAN, HM .

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1967, 26 (02) :200-+

[16] CALCIUM AND LONG-TERM TRANSMISSION DAMAGE FOLLOWING ANOXIA IN DENTATE GYRUS AND CA1 REGIONS OF THE RAT HIPPOCAMPAL SLICE [J].

KASS, IS ;

LIPTON, P .

JOURNAL OF PHYSIOLOGY-LONDON, 1986, 378 :313-334

[17]

LAPRESLE J, 1967, PROG BRAIN RES, V24

[18]

LOMO T, 1971, EXP BRAIN RES, V12, P18

[19] DOES CARBON-MONOXIDE HAVE A PHYSIOLOGICAL-FUNCTION [J].

MARKS, GS ;

BRIEN, JF ;

NAKATSU, K ;

MCLAUGHLIN, BE .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1991, 12 (05) :185-188

[20]

MEYER A, 1956, Proc R Soc Med, V49, P619

← 1 2 3 4 →