DETECTION OF A HUMAN INTRACISTERNAL A-TYPE RETROVIRAL PARTICLE ANTIGENICALLY RELATED TO HIV

被引：219

作者：

GARRY, RF

FERMIN, CD

HART, DJ

ALEXANDER, SS

DONEHOWER, LA

HONG, LZ

机构：

[1] CAMBRIDGE BIOTECH CORP,ROCKVILLE,MD 20850

[2] TULANE UNIV,SCH MED,DEPT PATHOL,NEW ORLEANS,LA 70112

[3] BAYLOR UNIV,DIV MOLEC VIROL,HOUSTON,TX 77030

来源：

SCIENCE | 1990年 / 250卷 / 4984期

关键词：

D O I：

10.1126/science.1701273

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Sjögren's syndrome is an autoimmune disease that is characterized by dryness of the mouth and eyes. The loss of salivary and lacrimal gland function is accompanied by lymphocytic infiltration. Because similar symptoms and glandular pathology are observed in certain persons infected with human immunodeficiency virus (HIV), a search was initiated for a possible retroviral etiology in this syndrome. A human intracisternal A-type retroviral particle that is antigenicaily related to HIV was detected in lymphoblastoid celis exposed to homogenates of salivary tissue from patients with Sjogren's syndrome. Comparison of this retroviral particle to HIV indicates that they are distinguishable by several ultrastructural, physical, and enzymatic criteria.

引用

页码：1127 / 1129

页数：3

共 35 条

[21] A HUMAN AUTOIMMUNE PROTEIN ASSOCIATED WITH U1 RNA CONTAINS A REGION OF HOMOLOGY THAT IS CROSS-REACTIVE WITH RETROVIRAL P30GAG ANTIGEN
QUERY, CC
KEENE, JD
[J]. CELL, 1987, 51 (02) : 211 - 220
[22] CELL KILLING BY ULTRAVIOLET-INACTIVATED HUMAN-IMMUNODEFICIENCY-VIRUS
RASHEED, S
GOTTLIEB, AA
GARRY, RF
[J]. VIROLOGY, 1986, 154 (02) : 395 - 400
[23] CHARACTERIZATION OF DNA-POLYMERASE AND RNA ASSOCIATED WITH A-TYPE PARTICLES FROM MURINE MYELOMA CELLS
ROBERTSON, DL
BAENZIGER, NL
DOBBERTIN, DC
THACH, RE
[J]. JOURNAL OF VIROLOGY, 1975, 15 (02) : 407 - 415
[24] PRESENCE OF CIRCULATING ANTIBODIES AGAINST GAG-GENE MULV PROTEINS IN PATIENTS WITH AUTOIMMUNE CONNECTIVE-TISSUE DISORDERS
RUCHETON, M
GRAAFLAND, H
FANTON, H
URSULE, L
FERRIER, P
LARSEN, CJ
[J]. VIROLOGY, 1985, 144 (02) : 468 - 480
[25] DNA-POLYMERASES OF NORMAL AND NEOPLASTIC MAMMALIAN-CELLS
SARNGADHARAN, MG
ROBERTGUROFF, M
GALLO, RC
[J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1978, 516 (04) : 419 - 487
[26] DOES HIV CAUSE SALIVARY-GLAND DISEASE
SCHIODT, M
GREENSPAN, D
LEVY, JA
NELSON, JA
CHERNOFF, D
HOLLANDER, H
GREENSPAN, JS
[J]. AIDS, 1989, 3 (12) : 819 - 822
[27] AN AIDS-RELATED CYTOTOXIC AUTOANTIBODY REACTS WITH A SPECIFIC ANTIGEN ON STIMULATED CD4+ T-CELLS
STRICKER, RB
MCHUGH, TM
MOODY, DJ
MORROW, WJW
STITES, DP
SHUMAN, MA
LEVY, JA
[J]. NATURE, 1987, 327 (6124) : 710 - 713
[28] RETRACTED: TARGET PLATELET ANTIGEN IN HOMOSEXUAL MEN WITH IMMUNE THROMBOCYTOPENIA (Retracted article. See vol. 325, 10.1056/NEJM199111213252106, 1991)
STRICKER, RB
ABRAMS, DI
CORASH, L
SHUMAN, MA
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1985, 313 (22) : 1375 - 1380
[29] DETECTION OF SERUM ANTIBODIES TO RETROVIRAL PROTEINS IN PATIENTS WITH PRIMARY SJOGRENS-SYNDROME (AUTOIMMUNE EXOCRINOPATHY)
TALAL, N
DAUPHINEE, MJ
DANG, H
ALEXANDER, SS
HART, DJ
GARRY, RF
[J]. ARTHRITIS AND RHEUMATISM, 1990, 33 (06): : 774 - 781
[30] A CONSERVED IDIOTYPE AND ANTIBODIES TO RETROVIRAL PROTEINS IN SYSTEMIC LUPUS-ERYTHEMATOSUS
TALAL, N
GARRY, RF
SCHUR, PH
ALEXANDER, S
DAUPHINEE, MJ
LIVAS, IH
BALLESTER, A
TAKEI, M
DANG, H
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1990, 85 (06) : 1866 - 1871

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