Interactions of human immunodeficiency virus type 1 transactivator of transcription protein with signal transduction pathways

The current state of knowledge investigating Tat interactions with signal transduction pathways is still in its infancy but has made significant progress toward understanding HIV pathology. This area is of great interest because Tat is among a small group of newly discovered RNA-based regulators of transcription. What is more important, however, are the implications of understanding these interactions concerning HIV-infected individuals. With the failure to develop effective HIV vaccines after years of development, it is becoming more feasible to conjecture therapies that target Tat as a means to keep HIV in its quiescent state rather than to eliminate the virus. In either case, the intense study of Tat and signal transduction pathways promises to provide a wealth of information about transcriptional control as well as the regulation of immune cell activation. © 1995.