TOLERANCE TO THE HYPOTHERMIC BUT NOT TO THE ANALGESIC EFFECT OF [D-TRP(11)]NEUROTENSIN DURING THE SEMICHRONIC INTRACEREBROVENTRICULAR INFUSION OF THE PEPTIDE IN RATS

被引：11

作者：

DUBUC, I ^{[1
]}

PAIN, C ^{[1
]}

SUAUDEAU, C ^{[1
]}

COSTENTIN, J ^{[1
]}

机构：

[1] FAC MED & PHARM ROUEN, CNRS,URA 1170,EUROPEAN INST PEPTIDE RES, UNITE NEUROPSYCHOPHARMACOL EXPTL, F-76803 ST ETIENNE DU ROUVRAY, FRANCE

来源：

PEPTIDES | 1994年 / 15卷 / 02期

关键词：

D-TRP(11)]NEUROTENSIN; CHRONIC INTRACEREBROVENTRICULAR ADMINISTRATION; TOLERANCE; ANALGESIA; BODY TEMPERATURE;

D O I：

10.1016/0196-9781(94)90017-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The peptidase-resistant derivative of neurotensin, [D-Trp11]neurotensin, has been continuously infused intracerebroventricularly (75 ng/h) with an osmotic minipump for 10 days. On several days during this infusion the locomotor activity, the body temperature. the food intake, the body weight, and the nociceptive response in the plantar test were measured. A nonsignificant decrease of body temperature and a sustained analgesic effect were observed at each time considered. The response to a test dose of [D-Trp11]neurotensin (75 ng per rat) injected intracerebroventricularly at the 10th day of the chronic infusion revealed a complete tolerance to its hypothermic effect. Thus, it appears that the analgesic effect of [D-Trp11]neurotensin is independent of a hypothermic or an incapacitating effect of the peptide and does not give rise to tolerance after a 10-day continuous administration, in contrast to the hypothermic effect.

引用

页码：303 / 307

页数：5

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