ANALYSIS OF A CIS-ACTIVE SEQUENCE MEDIATING CATABOLITE REPRESSION IN GRAM-POSITIVE BACTERIA

被引:173
作者
HUECK, CJ
HILLEN, W
SAIER, MH
机构
[1] UNIV CALIF SAN DIEGO,DEPT BIOL,LA JOLLA,CA 92093
[2] UNIV ERLANGEN NURNBERG,INST MIKROBIOL BIOCHEM & GENET,LEHRSTUHL MIKROBIOL,D-91058 ERLANGEN,GERMANY
关键词
BACILLUS; GRAM-POSITIVE BACTERIUM; CIS-ACTING ELEMENT; CARBON; REPRESSION; CATABOLISM; SEQUENCE ANALYSIS;
D O I
10.1016/0923-2508(94)90028-0
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
One form of catabolite repression (CR) in the Gram-positive genus, Bacillus, is mediated by a cis-acting element (CRE). We use here a consensus sequence to identify such elements in sequenced genes of Gram-positive bacteria. These are analysed with respect to position and type of gene in which they occur, CRE sequences near the promoter region are mainly identified in genes encoding carbon catabolic enzymes, which are thus likely to be subject to CR by a global mechanism. Functional aspects of CREs are evaluated.
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页码:503 / 518
页数:16
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