ANTIMICROBIAL ACTIVITY OF FLUORINATED 1,2-BENZISOTHIAZOL-3(2H)ONES AND 2,2'-DITHIOBIS(BENZAMIDES)

被引：32

作者：

CARMELLINO, ML ^{[1
]}

PAGANI, G ^{[1
]}

PREGNOLATO, M ^{[1
]}

TERRENI, M ^{[1
]}

PASTONI, F ^{[1
]}

机构：

[1] COMMISS EUROPEAN COMMUNITIES, JOINT RES CTR, INST ENVIRONM, FOOD & DRUG LAB MICROBIOL, I-21020 ISPRA, ITALY

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1994年 / 29卷 / 10期

关键词：

1,2-BENZISOTHIAZOL-3(2H)-ONE; 2,2'-DITHIOBIS(BENZAMIDE); ANTIFUNGAL ACTIVITY; ANTIBACTERIAL ACTIVITY; FLUOROSUBSTITUTION;

D O I：

10.1016/0223-5234(94)90132-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

Fluoro and trifluoromethyl derivatives of 1,2-benzisothiazol-3(2H)-ones and the 2,2'-dithiobis(benzamides) have been prepared and their antifungal and antibacterial activity evaluated. Several compounds were found highly active against fungi and Gram-positive microorganisms and a few derivatives displayed some activity against Gram-negative strains. Structure-activity relationships are proposed.

引用

页码：743 / 751

页数：9

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