KELATORPHAN AND RELATED ANALOGS - POTENT AND SELECTIVE INHIBITORS OF LEUKOTRIENE A(4) HYDROLASE

被引：29

作者：

PENNING, TD

ASKONAS, LJ

DJURIC, SW

HAACK, RA

YU, SS

MICHENER, ML

KRIVI, GG

PYLA, EY

机构：

[1] SEARLE RES & DEV, DEPT PROT BIOCHEM, CHESTERFIELD, MO 63198 USA

[2] SEARLE RES & DEV, DEPT ANALYT SCI, CHESTERFIELD, MO 63198 USA

[3] SEARLE RES & DEV, DEPT CELLULAR & MOLEC BIOL, CHESTERFIELD, MO 63198 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 21期

关键词：

D O I：

10.1016/0960-894X(95)00441-U

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The hydroxamic acid-containing peptide kelatorphan, a known inhibitor of enkephalin-degrading enzymes, is a potent, non-competitive inhibitor of leukotriene A(4) (LTA(4)) hydrolase. Analogs of kelatorphan were prepared and several significantly and selectively inhibited both the hydrolase and aminopeptidase activity of the enzyme.

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页码：2517 / 2522

页数：6

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