CATALYTIC ASYMMETRIZATION OF MESO-3,7-BIS-SILOXYCYCLOHEPTENE BY CHIRAL RHODIUM(I)-BINAP [2,2'-BIS(DIPHENYLPHOSPHINO)-1,1'-BINAPHTHYL] CATALYST - THE ENANTIOCONTROLLED ASYMMETRIC-SYNTHESIS OF (-)-(S)-PHYSOPERUVINE

被引：18

作者：

HIROYA, K ^{[1
]}

OGASAWARA, K ^{[1
]}

机构：

[1] TOHOKU UNIV,INST PHARMACEUT,SENDAI,MIYAGI 98077,JAPAN

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1995年 / 21期

关键词：

D O I：

10.1039/C39950002205

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Catalytic asymmetrization of meso-3,7-bis-tert-butyldimethylsiloxycycloheptene occurs in the presence of a chiral rhodium(I) binap catalyst to give optically active 4-tert-butyldimethylsiloxycycloheptanone in 70% ee after hydrolytic workup, the (R)-enantiomer of which has been transformed into (-)-(S)-physoperuvine, the major alkaloid of Physalis peruviana.

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页码：2205 / 2206

页数：2

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