VIP RESTORES NATURAL-KILLER-CELL ACTIVITY DEPRESSED BY HEPATITIS-B SURFACE-ANTIGEN

被引：10

作者：

AZZARI, C

ROSSI, ME

RESTI, M

CALDINI, AL

CARBONELLA, R

CIAPPI, S

VIERUCCI, A

机构：

[1] Department of Pediatrics, 50132 Firenze

来源：

VIRAL IMMUNOLOGY | 1992年 / 5卷 / 03期

关键词：

D O I：

10.1089/vim.1992.5.195

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Vasoactive intestinal peptide (VIP) has recently been shown to bind to human lymphocytes and modulate immune functions. The ability of VIP in restoring natural killer (NK) cell activity depressed by hepatitis B surface antigen (HBsAg) has been investigated in the present research. Human lymphocytes were incubated with HBsAg and, after washing, a 4-hr cytotoxicity assay was performed. VIP was coincubated with lymphocytes during the preincubation with HBsAg or, alternatively, throughout the cytotoxicity assay. The study revealed that VIP, either preincubated or coincubated in the 4-hr assay, strongly restores NK cell activity depressed by viral antigen. This is noteworthy considering that a number of lymphocyte modulators such as interferons fail in restoring viral-dependent NK cell activity depression. In contrast with previous reports, even when coincubated in the 4-hr assay, VIP is a strong activator of NK cell activity. Further studies will be required to understand which mechanisms are involved in the interrelation between VIP and NK cells during viral infections.

引用

页码：195 / 200

页数：6

共 36 条

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