DIFFERENTIAL EFFECT OF SUBCHRONIC DEXAMETHASONE TREATMENT ON SEROTONIN-2 AND BETA-ADRENERGIC RECEPTORS IN THE RAT CEREBRAL-CORTEX AND HIPPOCAMPUS

被引：37

作者：

KURODA, Y ^{[1
]}

MIKUNI, M ^{[1
]}

NOMURA, N ^{[1
]}

TAKAHASHI, K ^{[1
]}

机构：

[1] NATL CTR NEUROL & PSYCHIAT,NATL INST NEUROSCI,DIV MENTAL DISORDER RES,4-1-1 OGAWAHIGASHI,KODAIRA,TOKYO 187,JAPAN

来源：

NEUROSCIENCE LETTERS | 1993年 / 155卷 / 02期

关键词：

SEROTONIN-2; RECEPTOR; BETA-ADRENERGIC RECEPTOR; DEXAMETHASONE;

D O I：

10.1016/0304-3940(93)90706-Q

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effect of the 10-day dexamethasone administration on serotonin-2 (5-HT2) and beta-adrenergiC receptor binding sites was evaluated in rat cerebral cortex and hippocampus. The dexamethasone treatment (1, 2 and 5 mg/kg) significantly increased the density of the 5-HT2 receptor binding sites in a dose-dependent manner, whereas a decreased density of beta-adrenergic receptor binding sites was observed in rat cortex. In contrast, there were no significant differences in the densities of the 5-HT2 or beta-adrenergic receptor binding sites in rat hippocampUS using dexamethasone. The results suggest that dexamethasone differentially modulates the 5-HT2 and beta-adrenergic receptor binding sites in rat brain.

引用

页码：195 / 198

页数：4