SITE-SPECIFIC RECOMBINASES - TOOLS FOR GENOME ENGINEERING

被引：274

作者：

KILBY, NJ

SNAITH, MR

MURRAY, JAH

机构：

[1] N.J. Kilby, M.R. Snaith and J.A.H. Murray are in the Institute of Biotechnology, University of Cambridge, Cambridge, CB2 1QT, Tennis Court Road

来源：

TRENDS IN GENETICS | 1993年 / 9卷 / 12期

关键词：

D O I：

10.1016/0168-9525(93)90104-P

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Site-specific recombinases, from bacteriophage and yeasts have been developed as novel tools for manipulating DNA both in the test-tube and in living organisms. We discuss the characteristics of these enzyme systems, review their application in genetic and developmental studies and speculate on their future potential for large-scale directed modifications of eukaryotic genomes.

引用

页码：413 / 421

页数：9

共 51 条

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