BLOCK-COPOLYMER NANOPARTICLES OF ETHYLENE-OXIDE AND ISOBUTYL CYANOACRYLATE

被引：25

作者：

CHOI, YK ^{[1
]}

BAE, YH ^{[1
]}

KIM, SW ^{[1
]}

机构：

[1] UNIV UTAH,DEPT PHARMACEUT & PHARMACEUT CHEM,CTR CONTROLLED CHEM DELIVERY,SALT LAKE CITY,UT 84112

来源：

MACROMOLECULES | 1995年 / 28卷 / 24期

关键词：

D O I：

10.1021/ma00128a062

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Di- and triblock copolymers of poly(isobutyl cyanoacrylate) and poly(ethylene oxide) have been prepared and characterized. The synthesis involved capping of monohydroxyl- and dihydroxyl-terminated poly(ethylene oxide) with triphenylphosphine, followed by the zwitterionic polymerization of isobutyl cyanoacrylate with the triphenylphosphine-terminated poly(ethylene oxide) macroinitiator to yield the AB- or ABA-type block copolymers. The molecular weight and composition of the resulting block copolymers were close to theoretical values. Spherical nanospheres were prepared from the obtained block copolymers for potential biomedical applications.

引用

页码：8419 / 8421

页数：3

共 13 条

[1]

ALLEMANN E, 1993, EUR J PHARM BIOPHARM, V39, P173

[2] NANOPARTICLES AS CARRIERS FOR GROWTH-HORMONE RELEASING-FACTOR [J].

GRANGIER, JL ;

PUYGRENIER, M ;

GAUTIER, JC ;

COUVREUR, P .

JOURNAL OF CONTROLLED RELEASE, 1991, 15 (01) :3-13

[3] BIODEGRADABLE LONG-CIRCULATING POLYMERIC NANOSPHERES [J].

GREF, R ;

MINAMITAKE, Y ;

PERACCHIA, MT ;

TRUBETSKOY, V ;

TORCHILIN, V ;

LANGER, R .

SCIENCE, 1994, 263 (5153) :1600-1603

[4]

JOHNSTON DS, 1981, MACROMOL CHEM PHYS, V182, P407

[5]

JOHNSTON DS, 1981, MACROMOL CHEM PHYS, V182, P393

[6]

JOHNSTON DS, 1981, MACROMOL CHEM PHYS, V182, P421

[7]

Labarre D, 1994, P INT S CONTROL REL, V21, P91

[8] GRAFT CO-POLYMERIZATION BY MACROZWITTERION MECHANISM [J].

MIURA, M ;

AKUTSU, F ;

ITO, H ;

NAGAKUBO, K .

JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, 1979, 17 (05) :1565-1568

[9] HOMOGENEOUS ANIONIC POLYMERIZATION .1. MOLECULAR WEIGHTS OF POLYSTYRENE INITIATED BY SODIUM NAPHTHALENE [J].

MORTON, M ;

BRADLEY, LJ ;

MILKOVICH, R ;

MCINTYRE, DB .

JOURNAL OF POLYMER SCIENCE PART A-GENERAL PAPERS, 1963, 1 (01) :443-&

[10]

PEPPER DC, 1983, MAKROMOL CHEM, V184, P395

← 1 2 →