CRYSTAL-STRUCTURES OF SYNTHETIC ANALGETICS .5. DEXTROMORAMIDE

被引：8

作者：

BYE, E ^{[1
]}

机构：

[1] UNIV OSLO, DEPT CHEM, OSLO 3, NORWAY

来源：

ACTA CHEMICA SCANDINAVICA SERIES B-ORGANIC CHEMISTRY AND BIOCHEMISTRY | 1976年 / 30卷 / 02期

关键词：

D O I：

10.3891/acta.chem.scand.30b-0095

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The molecular and crystal structure of dextromoramide was determined by X-ray methods. The crystals are orthorhombic, space group P212121 with unit cell dimensions a = 9.720(4) .ANG.; b = 12.226(3) .ANG.; c = 18.381(3) .ANG.. The structure was determined by direct methods and the model refined to an R-value of 0.036 for 1788 observed reflections. The mean e.s.d.''s in bond lengths and angles are 0.004 .ANG. and 0.3.degree., respectively. The morpholine moiety is nearly in anti position relative to the quaternary C atom C6, the pertinent angle C6-C7-C9-N2 being -159.4.degree.. The pyrrolidine ring has the envelope conformation and the amide group is strictly planar. The conformations of some acyclic analgetics are discussed.

引用

页码：95 / 100

页数：6

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[11] APPLICATION OF PHASE RELATIONSHIPS TO COMPLEX STRUCTURES .3. OPTIMUM USE OF PHASE RELATIONSHIPS [J].