NEUROBIOLOGICAL MODELS OF OBSESSIVE-COMPULSIVE DISORDER

被引：81

作者：

RAUCH, SL

JENIKE, MA

机构：

[1] MASSACHUSETTS GEN HOSP, DEPT PSYCHIAT, BOSTON, MA 02114 USA

[2] HARVARD UNIV, SCH MED, BOSTON, MA 02115 USA

来源：

PSYCHOSOMATICS | 1993年 / 34卷 / 01期

关键词：

D O I：

10.1016/S0033-3182(93)71924-6

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

The authors review current neurobiological models of obsessive-compulsive disorder (OCD). The rationale for anatomically based models is outlined and selected brain regions of interest are discussed. The authors conclude that there is abundant evidence to implicate multiple brain regions as sites of abnormality in OCD. A review of neuropharmacological concepts related to the serotonergic (5-HT) hypothesis of OCD is also presented. The authors conclude that antiobsessional agents may well have therapeutic effects via the 5-HT system, yet there is little unequivocal evidence to suggest an underlying abnormality in the 5-HT system. A comprehensive neurobiological model of OCD must acknowledge the interrelationship between multiple transmitter systems and integrate anatomical with neuropharmacological concepts.

引用

页码：20 / 32

页数：13

共 104 条

[51] NEUROLOGICAL FACTORS IN OBSESSIVE-COMPULSIVE DISORDER - 2 CASE-REPORTS AND A REVIEW OF THE LITERATURE [J].